»   Medication   »   Actoplus Met (Pioglitazone + Metformin) – oral drug for treating type 2 diabetes mellitus that cannot be controlled by diet and exercise

Actoplus Met (Pioglitazone + Metformin) – oral drug for treating type 2 diabetes mellitus that cannot be controlled by diet and exercise

Buy Actoplus MetGeneral information

Actoplus Met is a medication for treating type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus). Actoplus Met generic are pioglitazone and metformin, which are both antidiabetic drugs that are especially effective when used together. Actoplus Met, as well as its extended release form Actoplus Met XR, can be prescribed to be taken either alone or in combination with other medications. Additionally, the patients need to comply with the diet and exercise recommendations when receiving Actoplus Met or Actoplus Met XR treatment.

Buy Actoplus Met (Pioglitazone + Metformin)

How Actoplus Met Works

As Actoplus Met is a combination of two medications, it refers to the biguanide and thiazolidinedione classes of drugs. Pioglitazone component reduces the insulin resistance of the body cells, which lets them normally absorb glucose and thus let the blood glucose level stay normal. Metformin component suppressed glucose production in the liver and decreases glucose absorption in the intestines. The combination of these two ways of controlling blood glucose levels lets manage type 2 diabetes incredibly successfully.

How Should I Use Actoplus Met

When following the prescribed Actoplus Met dosage regimen, keep in mind the following:

  • Actoplus Met is taken by mouth with food.
  • Actoplus Met should be taken regularly according to the schedule to get the maximum effect from the treatment.
  • Actoplus Met is better to take the same time each day.
  • Actoplus Met treatment should not be stopped even if you start feeling better.
  • Try not to miss any Actoplus Met mg dose.

You can buy Actoplus Met in the following forms:

  • Actoplus Met 15/500 mg
  • Actoplus Met 15/800 mg

If you are prescribed to take the extended release form of Actoplus Met, you can buy it in the following forms:

  • Actoplus Met XR 15 mg/1000 mg
  • Actoplus Met XR 30mg/1000 mg

Actoplus Met dosage should be changed only by your doctor.

What if I miss a dose? If you missed your Actoplus Met dose, you need to take it as soon as you remember. If it’s almost time for the next dose according to your regular schedule, you should skip the missed dose. Never take 2 doses of Actoplus Met or Actoplus Met XR at once.

What happens if take a bigger dose? If you overdose on Actoplus Met, you may have lactic acidosis, the most common symptoms of which include weakness, sleepiness, pain in muscles, stomach ache, slow heart rate, shortness of breath, fainting, etc. Actoplus Met overdose also causes hypoglycaemia with such symptoms as sweating, shaking, dizziness, increased hunger, blurred vision, etc. If you overdose on Actoplus Met, seek emergency medical assistance immediately.

How should I store Actoplus Met? Actoplus Met should be stored in a tightly closed container, in a place safe from children and pets, at the temperature range of 68-770 F (20-250 C). Keep your Actoplus Met medication away from humidity and moisture.

Where to Buy Actoplus Met

With a prescription you can buy Actoplus Met or Actoplus Met XR in the prescribed dosage in any drugstore. A more convenient and often more affordable way is to buy Actoplus Met online. In our online store, you can buy Actoplus Met 15/500 mg and Actoplus Met 15/800 mg.

Safety – learn before using

As Actoplus Met is a very powerful antidiabetic drug, learn the following safety information extremely carefully.


These medical conditions are contraindicative to Actoplus Met treatment. Inform your health care provider of you have any of the following:

  • Hypersensitivity to any components of Actoplus Met.
  • Type 1 diabetes mellitus (insulin-dependent diabetes mellitus).
  • Moderate or severe heart failure.
  • Recent history of a stroke, heart attack, or current shock.
  • Severe infection.
  • Low blood oxygen levels.
  • Problems with liver or kidneys.
  • High blood ketone or acid levels.
  • Severe dehydration.
  • Over 80 years old and no kidney function test carried out.
  • History of acute liver diseases (including jaundice) while undergoing treatment by troglitazone (which acts similarly to pioglitazone).

Alerting Medical Conditions

If any of the following medical conditions apply to you, inform your health care provider as soon as possible, as these conditions may interact with Actoplus Met treatment:

  • Current pregnancy, planned pregnancy, and lactation (breast-feeding).
  • Any allergic reactions to products, medicines, and other substances.
  • Current treatment with other drugs, current intake of herbal preparations and food supplements.
  • History of problems with heart, liver, lungs, breathing, thyroid, stomach, bowel, adrenal cortex and pituitary gland, eyes and vision, lactic acidosis, bladder cancer.
  • Fever, infection, moderate and severe burns, recent injury.
  • History of bone fracture, weak bones, or low calcium intake.
  • Planned surgery or lab procedures.
  • Vomiting, diarrhea.
  • Anemia.
  • Fluid retention or swelling problems.
  • Dehydration.
  • Low levels of blood calcium or vitamin B12.
  • Poor health and malnutrition.
  • History of alcohol abuse or current alcohol consumption.
  • Current beta-blocker treatment.

Interaction with Other Drugs

Some drugs may interact with Actoplus Met. If you are currently taking or are planning to take any of the following, let your health care provider know before starting Actoplus Met treatment:

  • Drugs increasing the risk of Actoplus Met side effects:
    amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin, gemfibrozil.
  • Drugs either increasing or decreasing blood sugar levels:
    calcium channel blockers, corticosteroids, diuretics, estrogen, hormonal contraceptives, insulin, isoniazid, nicotinic acid, oral antidiabetics, phenothiazine, phenytoin, sympathomimetics, thyroid hormones.
  • Drugs decreasing the effectiveness of Actoplus Met:
  • Drugs the effectiveness of which may be decreases or the risk of side effects of which can be increases:

Possible Side Effects

Some patients may experience minor or severe Actoplus Met side effects. You need to be fully aware of them.

Common Minor Actoplus Met Side Effects:

  • Nausea, vomiting.
  • Stomach upset, indigestion.
  • Headache.
  • Mild weight gain.

Severe Actoplus Met Side Effects:

  • Severe allergic reactions – breathing difficulties, swelling of the mouth and face, rash, etc.
  • Blurred vision.
  • Dizziness, fainting.
  • Chest pain and discomfort, difficult breathing.
  • Painful urination.
  • Fever, chills, persistent sore throat.
  • Unusual drowsiness, tiredness, weakness.
  • Bone pain, muscle pain, stomach pain.
  • Slow or irregular heartbeat.
  • Jaundice (yellowing of eyes or skin).
  • Sudden weight gain.
  • Pale stools.
  • Persistent loss of appetite.

Should you experience any of the severe Actoplus Met side effects, seek emergency medical attention immediately. You should also contact you doctor in case you are not responding to Actoplus Met treatment or if the diabetes symptoms get worse.

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