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Avandamet (Roziglitazone + Metformin) – oral drug for treating type 2 diabetes mellitus

Buy AvandametGeneral information

Avandamet is a medication prescribed to patients with type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus). Avandamet is a popular combination of two antidiabetic drugs – Roziglitazone (marketed as Avandia) and metformin (marketed as Glucophage). Avandamet is used along with keeping to a special diet and exercise program. Avandamet can be used in combination with other antidiabetic drugs.

Buy Avandamet (Roziglitazone + Metformin)

How Avandamet Works

Avandamet is a combination of two drugs referring to the biguanide and thiazolidinedione classes. Pioglitazone, a thiazolidinedione class drug, makes the body cells less resistant to the action of insulin, which enables them absorb more glucose and, in such a way, make the blood glucose levels lower. Metformin, a biguanide class drug, decreases the amount of glucose produced by the liver and later absorbed by the intestines, so that the blood sugar level become lower.

How Should I Use Avandamet

Take Avandamet as prescribed by your doctor. Additionally, study the information indicated on the label of Avandamet. Keep in mind the following:

  • Avandamet is taken by mouth with food.
  • It is recommended to take Avandamet the same time each day.
  • Compliance with the regular schedule is vital for the maximum benefit from Avandamet therapy.
  • Do not stop taking Avandamet even if you start feeling better.
  • Do not miss prescribed Avandamet doses.

You can buy Avandamet in the following forms:

  • Avandamet 1/500 mg
  • Avandamet 2/500 mg
  • Avandamet 4/800 mg
  • Avandamet 2/1000 mg
  • Avandamet 4/1000 mg

Only your doctor can change your Avandamet dosing.

What if I miss a dose? The missed Avandamet dose should be taken as soon as you remember. Make sure you take it with food. Skip the missed Avandamet dose if it’s almost time for the next one. Do not take doubled Avandamet dose.

What happens if take a bigger dose? Avandamet overdose may cause lactic acidosis and hypoglycaemia. Common symptoms of lactic acidosis include sleepiness, weakness, fainting, muscle pain, stomach ache, slow heart rate, shortness of breath, etc. Common hypoglycaemia symptoms include dizziness, blurred vision, sweating, shaking, increased hunger, etc. If you overdose on Avandamet, seek emergency medical assistance immediately.

How should I store Avandamet? Avandamet should be stored in a tightly closed container away from moisture and light at 770 F (250 C). It is permitted to briefly store Avandamet at the temperature range of 59-860 F (15-300 C). Keep Avandamet medication away from children and pets. Do not store Avandamet in the bathroom.

Where to Buy Avandamet

You can buy Avandamet either in a drugstore or online. In the former case, you need to have a prescription from your doctor, and in the latter case, prescription may not be necessary. In online drugstores like ours, you can buy Avandamet at low prices and often at discounts. We offer to buy Avandamet in any dosage form that you need.

Safety – learn before using

To avoid possible harmful effects on your health, carefully study the following safety information on Avandamet. It includes contraindication to Avandamet therapy, as well as alerting medical conditions and drugs that may increase the risks of treatment with Avandamet.


Avandamet therapy is contraindicative to patients having the following diseases or matching the following criteria. If any of the below listed points apply to you, inform your health care provider as soon as possible and do not start Avandamet therapy:

  • Hypersensitivity to any ingredient of Avandamet.
  • Type 1 diabetes mellitus (insulin-dependent diabetes mellitus).
  • Severe infection.
  • Moderate or severe heart failure.
  • Recent history of a stroke, heart attack, or current shock.
  • Low blood oxygen levels.
  • High blood ketone or acid levels.
  • Problems with liver or kidneys.
  • Severe dehydration.
  • Planned surgery or laboratory procedures.
  • Over 80 years old and no kidney function test carried out.
  • History of liver diseases (including jaundice) while undergoing therapy with troglitazone (which acts similarly to Avandamet).
  • Current intake of nitrates, or treatment with insulin.

Alerting Medical Conditions

These medical conditions may interact with Avandamet making the treatment hazardous. Inform your health care provider if you have any of the following:

  • Pregnancy (current or planned), and lactation (breast-feeding).
  • Current treatment with other drugs, current intake of herbal preparations and dietary supplements.
  • Any allergic reactions to products, drugs, and other substances.
  • History of problems with heart, liver, lungs or breathing, thyroid, stomach or bowel, adrenal cortex or pituitary gland, eyes or vision.
  • History of lactic acidosis or bladder cancer.
  • Fluid retention or swelling problems.
  • Dehydration.
  • Fever, infection, moderate and severe burns, recent injury.
  • Vomiting, diarrhea.
  • Anemia.
  • Low levels of blood calcium or vitamin B12.
  • Poor health and malnutrition.
  • History of alcohol abuse or current alcohol consumption.
  • Planned surgery or laboratory procedures.
  • Current beta-blocker treatment.

Interaction with Other Drugs

Before starting treatment with Avandamet, study the list of drugs that may interact with Avandamet. If you are currently taking or are planning to take any of the following, inform your health care provider:

  • Drugs increasing the risk of heart problems:
    insulin, nitrates.
  • Drugs increasing the risk of Avandamet side effects:
    amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin, gemfibrozil.
  • Drugs either increasing or decreasing blood sugar levels:
    calcium channel blockers, corticosteroids, diuretics, estrogen, hormonal contraceptives, isoniazid, nicotinic acid, oral antidiabetics, phenothiazine, phenytoin, sympathomimetics, thyroid hormones.
  • Drugs decreasing Avandamet effectiveness thus leading to hyperglycaemia:
  • Drugs that may lose their effectiveness or will more likely cause side effects when used together with Avandamet:

Possible Side Effects

You may experience some Avandamet side effects. If minor Avandamet side effects are persistent or become bothersome, contact your health care provider to get qualified medical assistance.

Common Minor Avandamet Side Effects:

  • Decreased appetite, dry mouth, increased salivation.
  • Nausea, vomiting, diarrhea, constipation.
  • Pounding in the chest.
  • Rapid heartbeat.
  • Flu.
  • Attention disturbance, dizziness, drowsiness, nervousness, restlessness, sleeplessness.
  • Sweating, weakness.
  • Headache, lightheadedness.
  • Impaired coordination/balance, clumsiness.
  • Joint pain.
  • Blurred vision.
  • Skin inflammation.
  • Weight change.
  • Decreased sex drive.

Severe Avandamet Side Effects:

  • Severe allergic reactions – hives, rash, breathing difficulties, tightness in chest, swelling of the mouth, face, tongue, and lips, etc.
  • Fainting.
  • Involuntary movements
  • Depression.
  • Memory impairment.

Seek emergency medical assistance if any of the severe Avandamet side effects occur. You need to also contact your doctor as soon as possible in case Avandamet therapy does not help manage diabetes or worsens diabetes symptoms.

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